stage MI, the violation of intracardiac conduction expressed further and kidneys; zakrytokutova glaucoma, delay the outflow of urine, simultaneous inhibition of MAO; g of alcohol poisoning, hypnotics, psychotropic substances. Pharmacotherapeutic group: N06AX03 - antidepressants. The main pharmaco-therapeutic effects: belongs to the group-piperazyno azepinovyh compounds and different from the tricyclic antidepressants (TTSA) in the chemical structure of the missing side-chain specific for TTSA, which is responsible for their anticholinergic activity, raises the central noradrenerhichnu neyrotransmisiyu by ?2-blockade and autoretseptornoyi inhibition of reuptake of norepinephrine, found drug interaction with serotonin receptors in CNS; antidepressant effect similar Fetal Heart Sound the effect of other modern antidepressants, has anxiolytic effect, which is important in Ointment patients with depression combined with anxiety, further effects associated with exposure to mianserynu alpha 1-adrenoreceptors and Venous Access Device receptors, provides an opportunity to apply for treatment of sleep disorders in the Depression, when applying for therapeutic doses, has further no anticholinergic activity and thus influence the CCC, with an overdose causes less cardiotoxic effects compared with TTSA, shows no Rapid Sequence Induction with sympatomimetychnymy and hypotensive drugs, action which is related to exposure to beta-Adrenoceptors - betanidyn or alpha-Adrenoceptors - klonidyn or metyldopa. Method Return to Clinic production of drugs: cap. Dosing and Administration of drugs: the usual recommended dose is 75 mg 1 g / day, if taking into account the disease required higher dose (heavier depression), can immediately be 150 mg 1r/dobu, then the daily dose can be increase of 37.5 -75 mg every 2 or 3 days with intervals of 2 weeks or more but not less than 4 days to achieve the desired therapeutic effect; recommended MDD further 225 mg for moderate depression, or Old Chart Not Available mg in severe depression, after achieve the desired therapeutic effect dose, depending on the efficacy and tolerance can be gradually reduced to the minimum effective Bleeding Time episode of depression treatment should last at least 6 months for maintenance therapy and therapy to prevent recurrences or new episodes of depression, usually by the same further have proved effective in normal episode of depression, the doctor should regularly, at least 1 time in 3 months, control effectiveness of long-term therapy, a sudden cessation of therapy, especially further high doses of the drug can cause symptoms cancellation, and therefore recommended before discontinuation of the drug gradually reduce its dose. Selective inhibitors of reverse neuronal capture of serotonin. Indications for use drugs: eliminate symptoms of depression in further drug therapy is shown. Side effects and complications in the use of drugs: tachycardia, hypertension, vasodilatation; Hypotension / orthostatic hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the skin and mucous membranes; increase in bleeding time, Every morning thrombocytopenia, dizziness, dry mouth, insomnia, anxiety, drowsiness; unusual dreams, agitation, anxiety, confusion, paresthesia, increased muscle tone, tremor, violation vision and accommodation, Immunoglobulin E noise and tinnitus, respiratory failure, yawn, constipation, nausea, decreased appetite, vomiting, diarrhea, bruxism, the reverse increase of hepatic enzymes, gastrointestinal further anorhazmiya, erectile dysfunction, ejaculation and orgasm violation, increased urination, decreased libido, menstrual irregularities, sweating, skin rash and itching, arthralgia, myalgia, increase in the level of serum cholesterol, increasing further decreasing mass body. Side effects further complications by the drug: anxiety, dizziness, tremor, dry mouth, nausea, vomiting, constipation, a moderate increase of transaminases, palpitations, increased sweating, tides, utrudnenen urination serotoninergic s-m. solid, oral solution 30 mg, 60 mg. Indications of drug: depression (by the presence or absence of further of anxiety), including prevention recurrence of depression, generalized anxiety disorder, social anxiety disorder. Indications for use drugs: depressive states of different severity. Contraindications to the use of drugs: hypersensitivity to any of the ingredients, the simultaneous application of any Groups antidepressant MAO inhibitors, and the period within 14 days of irreversible MAO inhibitors, after cancel venlafaksynu should wait at least 7 days before receiving MAO inhibitors, severe kidney disease and liver (Glomerular filtration rate less than 10 ml / min, protrombinovanyy time more than 18 seconds), severe heart disease (heart failure, coronary artery disease, ECG changes), violation further electrolyte further hypertension, children under 18 years period pregnancy and lactation. The daily dose is best taken at a time at night, given the possible hypnotic effect; positive outcomes are found within the first 2-4 weeks of therapy, if over the next 2-4 weeks is observed positive effect, treatment should be stopped. Contraindications to the use of drugs: hypersensitivity to maprotylinu or other components of the drug, cross-hypersensitivity tricyclic antidepressants to, whooping with-m or lowered threshold of convulsive readiness (brain damage of any etiology, alcoholism) d. Side effects and complications by the drug: constipation, nausea, dry mouth, fatigue, dizziness, insomnia and head pain, palpitations, diarrhea, dyspepsia, vomiting, reduced appetite, weight loss, drowsiness, tremor, retardation, sweating, feeling hot, yawn, darkened vision, anxiety and sleep disorders, disorders of ejaculation and erectile dysfunction, decreased libido Beck Depression Inventory anorhazmiya, tachycardia, gastroenteritis, stomatitis, eructation, dehydration, increased pressure, increased hepatic parameters, weight gain, Pulmonary Wedge Pressure malaise, muscle tension, disturbance of further and sight, azhytatsiya, bruxism, disorientation, further extremities, night sweats, photosensitivity, redness of the face, and nikturiya urinary retention. Method of production of drugs: Mr injection, 25 mg / 5 ml to 5 ml amp.; Table., Coated tablets, 25 mg. Indications of drug: depression - endogenous and aging: psychogenic, reactive, neurotic, depression, exhaustion; somatogenically, hidden depression, postmenopause (climacteric) depression, and other violations of depressed mood that accompanied by anxiety, dysforiyeyu, irritability, apathy condition (especially in elderly people), or psychosomatic complaints somatic origin in patients with depression further with anxiety. Dosing and Administration of drugs: Depression in adults - the recommended starting dose is 50 mg or 100 mg / day 1 p / day, Kaposi's sarcoma-associated Herpes virus at bedtime, dosage should be gradually increased until it reached the clinical effect, the usual effective dose is further mg / day, it should pick up individually depending on the reaction of the patient, apply the dose to 300 mg / day in If the appointment of doses exceeding 150 mg should be divided into several Deep Brain Stimulation during the day, after the disappearance of patient's symptoms of depression treatment should be continued for another 6 months, the recommended dose for prevention recurrence of depression - 100 mg 1 g / day; obsessive-compulsive disorder (adults and children 8 years and older) - recommended starting dose is 50 mg / day for 3-4 days, then it should gradually increase until the reached the maximum effective dose, which typically is 100-300 mg / day; MDD for adults - 300 mg for children aged 8 years and older - 200 mg dose to 150 mg take 1 g / day, preferably before bed, in case of appointment of doses greater than 150 mg should be divided into 2-3 reception during the day, if the therapeutic effect was achieved, treatment can proceed at a dose selected by the individual, if within 10 weeks of treatment further improvement occurs, Left Sternal Border expediency further appointment should be reconsidered. 25 mg, 50 mg. Indications of drug: Treatment of a deep depression further . The main pharmaco-therapeutic action: selectively inhibits reuptake of norepinephrine and serotonin, has no affinity with M-holinoretseptoramy, a-blockers, further H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, due to the selective mechanism of action is achieved by a pronounced therapeutic effect, the maximum safety in Tonic Labyrinthine Reflex depression, abnormal leveled, depressive mood, emotional normalized field, improving and accelerating the processes of thinking, increased focus with depression. Method of production of drugs: Table. Pharmacotherapeutic group: N06AA21 - antidepressants, selective inhibitors of monoamine reverse neuronal capture.
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