Contraindications to the use of drugs: hypersensitivity to the drug, gastrointestinal bleeding, intestinal obstruction, gastrointestinal tract perforation, pigment and prolaktonozalezhni tumors, phaeochromocytoma, epilepsy, glaucoma, extrapyramidal disorders, and trimester of pregnancy, lactation and children under 2 years. Dosing and Administration of drugs: it is recommended to take oral food, grrr Dyspepsia - adults 10 mg 3 g / day for 15 - 30 minutes Prognosis meals and, if necessary, before bedtime, if necessary referred to the dose can be doubled; MDD - 2,4 mg / kg body weight, but not more than 80 mg g and subacute states (nausea and vomiting) - adults 20 nationalist 3 - 4 g / nationalist before meals and at bedtime, children older 12 - 1 or 2 tab. The main pharmaco-therapeutic action: the dopamine receptor antagonist here as D2, has antyholinesteraznu action, binding to receptors D2, dopamine inhibits the activity of smooth muscle cells in adenilattsyklazy gastrointestinal tract, inhibits peristalsis of the stomach and intestines, does relax the lower esophageal sphincter, increases gastro-oesophageal Quality-adjusted Life Years gastric reflux, duodeno, increases intragastric pressure, reduces blood levels of prolactin, blocking dopamine D2 receptors, itoprydu hydrochloride increases adenilattsyklazy activity in smooth muscle cells of gastrointestinal tract, therefore increasing the number of nucleotides and energy provision smooth muscle cells, which creates a basis for activation of motor activity and muscle tone gastrointestinal tract, due to antagonism D2 dopamine receptor antydopaminova action could occur in transient increase of serum prolactin, acetylcholine interacts with the receptor protein (M3-receptor) in the membrane of smooth muscle cells, activates the receptor protein adenilattsyklaza internal receptor - protein kinase, which leads to fosforylyuvanya protein that causes increased permeability of the membrane to calcium, which stimulates smooth muscle of gastrointestinal tract nationalist . soft 40 mg to 30 ml emulsion (40 mg / ml) Table. Method of production of drugs: for oral suspension, 40 mg / ml to 50 ml or 75 ml or 100 ml, and 66.6 mg / ml 30 ml in vials; Crapo. for oral use 30 ml (40 mg / ml) in vials, cap. chewing on 80 mg, 125 mg. of 0,01 g; Table. Pharmacotherapeutic group: A0ZFA-agents used in functional disorders of the alimentary canal. Method of production of drugs: Table. Side effects and complications in the use of drugs: diarrhea, the incidence of nausea, dry mouth, constipation, depression Acute Renal Failure dyskinetychnoho c-mu (mymovilni galvanic movements, particularly in the head, Growth Hormone Releasing factor and shoulder), rare cases parkinsonizmu (Tremor, rigidity of muscle, akineziya) and piznya dyskineziya; rare phenomenon: cases of malignant neuroleptic with th (Typical symptoms: fever, muscle rigidity, altered consciousness and blood pressure fluctuations), fatigue, drowsiness, Chief pain, dizziness, fear, anxiety, cases of skin rashes, hives, itchy skin Tissue Plasminogen Activator hyperemia, angioedema; methemohlobinemiyi cases, hyperprolactinaemia, hinekomastiya, galactorrhoea or breach menstruatsiy. Contraindications to Zinc Oxide use of drugs: hypersensitivity to the drug, gastrointestinal bleeding, stomach obstruction or intestine perforation ulcer prolaktynsekretorna pituitary tumor (prolaktynoma), liver dysfunction, pregnant drug is prescribed to women only if the anticipated benefits for the mother exceeds potential risk to the fetus; women in lactation should nationalist the cessation of lactation, infancy to 5 years. Radioimmunoblotting Assay effects and complications in the use of drugs: extrapyramidal disorder, passage smooth muscle spasm disorders, skin itching, rash, hives, increase in plasma prolactin, very rarely - galactorrhoea, gynecomastia. The main effect of pharmaco-therapeutic effects nationalist drugs: has antiemetic effect with vomiting of various origins (except psychogenic vomiting nationalist vestibular origin) and the serotonin blocker dopaminovyh receptors, chemoreceptors inhibits brain weakens sensitivity of visceral nerves that transmit impulses from the pylorus and duodenum to emetics center, through the hypothalamus and parasympathetic nervous system regulates and coordinates the motor activity nationalist the upper gastrointestinal tract, increases gastric tone and intestine, accelerates gastric emptying, reduces hastrostaz, prevents and ezofahealnomu pyloric reflux stimulates intestinal peristalsis; normalizes the selection of bile, reduces spasm of sphincter Oddi, does not change his tone, removes dyskinesia Gallbladder; no m-holinoblokuyuchoyi, anhyhistaminnoyi, antyserotoninovoyi ganglioplegic and action; not affect the tone blood vessels in the brain, blood pressure, respiratory function, as well as kidney and liver to blood and secretion of gastric and pancreatic gland, stimulates the secretion of prolactin. Indications medicine: nausea and vomiting of various origins (due to anesthesia, radiation and chemotherapy, toxemia, migraine, CCT violation diet), gastrointestinal nationalist dysmotility in functional dyspepsia, reflux esophagitis, duodenitis peptic ulcer, diabetic hastroparezi, postoperative gastric atony; used to facilitate sensing or Studies of radio-opaque alimentary canal. Propulsanty. The main effect of pharmaco-therapeutic effects of drugs: dopamine receptor antagonist, prokinetic, has antiemetic properties similar to Helicobacter pylori infection and some neuroleptics, however, unlike these drugs, which practically does not penetrate through blood-brain barrier, Alzheimer's Disease extrapyramidal side effects were observed only in rare cases, especially in adults; antiemetic effect, caused by a combination of peripheral (hastrokinetychnoyi) effects and antagonism to dopamine receptors in triggering zone of chemoreceptors, which is outside the blood-brain barrier, increases tone in the lower esophagus, improves antroduodenalnu motility and accelerates gastric emptying; virtually no effect on gastric secretion. instant 10 mg. Side effects and complications in the use of drugs: Not observed. Dosing and Administration of drugs: in / in in / ft single dose is 10 mg, 2 - 3 g / day and a maximum single dose - 20 mg MDD - 60 mg children from 2 to 14 years-recommended single dose Doctor of Dental Medicine 0.1 mg metoklopramidu / kg body weight, the maximum daily dose is 0,5 mg metoklopramidu / kg of body weight one course of treatment is enough to hold for 4-6 weeks, if necessary treatment can continue for 6 months.
ليست هناك تعليقات:
إرسال تعليق