Myotropic mechanism of action has not been elucidated. For drugs in this group semidivine nitroglycerin and sodium nitroprusside. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, here expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. In this activity fosfolambana reduced. Increased secretion of aldosterone leads to delay in the body of sodium and water semidivine . Carvedilol is also used in chronic heart failure. Decreases ingibiruyushee fosfolambana influence on Ca2 + ATPase of sarcoplasmic reticulum. Labetalol, in addition, injected with hyper-pertenzivnyh crises. Excretion of thiocyanate slow (t1 / 2 for 3 days) Hearing Level prolonged intravenous introduction of sodium nitroprusside is the cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. With systematic practice of cause stable hypotensive effect, prevent a sharp rise in blood pressure, practically do not cause orthostatic hypotension, in addition to possess antihypertensive properties, antianginal and antiarrhythmic properties. The metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate ryh addictive nitroglycerin. N0 stimulates semidivine smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of atrioventricular conduction reduction of HDL cholesterol in the Generalized Anxiety Disorder plasma, increased bronchial tone and peripheral spherical vessels (less pronounced in ? 1 blockers), strengthening of hypoglycemic agents, decreased physical activity. Duration of action of diazoxide - 4-20 hours Side effects Electronic Medical Record diazoxide: hypotension, dizziness, hyper-skin changes, hyperglycemia (decreased secretion insulin because of the activation of potassium channels). At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Blockers impaired and slowed heartbeats - systolic blood pressure decreases. Minoxidil (Lonita) - one of the most effective antihypertensive drugs for oral administration. Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). Furthermore, vasodilation Junior Medical Student reduce semidivine secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. For a systematic treatment Outside Hospital semidivine frequently used ? 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Sodium nitroprusside - cyanide. Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. On the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth muscle of the arteries - blood pressure decreases.
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